The solution lies in The very fact there are multiple isoforms of every troponin subunit which happen to be encoded by distinct genes, many of which happen to be expressed selectively in cardiac muscle mass. Although TnI and TnT have distinctive cardiac and skeletal isoforms, they share a standard isoform of TnC: the slow-twitch skeletal muscle mas
The dissimilarities in AA sequences permitted enhancement of quantitative assays for cTnI/T. Most cTn assays are non-aggressive enzyme-connected immunosorbent assays (ELISA) depending on the sandwich theory, utilizing the high specificity and affinity of antibodies.31 The assay is predicated over a capture antibody which binds to a particular epito
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